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Bristol

Synaptic Self: How our brains become who we are by Joseph LeDoux,
Viking, $29.95 ISBN 0670030287

If you think of your “self” as that special inner being that makes your
decisions and has your experiences, then be warned that this book is not about
that sort of self. It does not even consider the odd fact that we think of
ourselves as something different from our brains. The “self” of the title is
more like personality, or the sum of our brain’s activities.

Synaptic Self succeeds as a clearly written overview of how synapses
work and how neurotransmitter and neuromodulator substances carry out their
functions. LeDoux outlines a “mental trilogy”: the mind as an amalgam of
cognition, emotion and motivation. When so many authors concentrate entirely on
cognition, it is refreshing to have the balance redressed—even if much of
the research reported is on fear in rats, and the section on human love is based
on pair-bonding in prairie voles.

LeDoux argues that synaptic changes, not specific molecules, underlie mental
illness. He gives fascinating detail on how synapses change in normal memory, in
the processes of ageing and in Alzheimer’s disease. But his stirring conclusion
that “You are your synapses” is less than convincing.

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